Novartis CEO: We need to re-think the blockbuster

Big Pharma companies have hit a wall chasing billion-dollar drugs. Novartis CEO Joseph Jimenez outlines a new paradigm for blockbuster medications.

FORTUNE -- Big Pharma is still big, but its business model is dying. For years, the game in pharmaceuticals has been to research, discover and then fiercely defend billion-dollar drugs.

But several mighty drug companies are losing the rights to exclusively own the formulas for best-selling drugs. Take Pfizer (PFE), which MORE

How IKEA can get back on the horse after a meat scandal

IKEA and other companies can regain consumer trust after dealing with products contaminated with horsemeat. The trick is to be the vindicator, not the victim.

FORTUNE -- Many balk at the idea of biting into Seabiscuit. The cultural taboo around eating horse is one reason why the public has had such a negative reaction to the news that certain European suppliers have been shipping beef contaminated with horsemeat.

On Monday, news broke MORE

Trina Turk: The no-drama fashionista

Designer Trina Turk talks to Fortune about the pros and cons of launching a line without a business plan and how to stay low drama in a cutthroat industry.

The auto industry's best-kept secret

Automakers are among the most efficient corporate recyclers in the U.S. Why do we never hear about it?

The new United States of Booze

Nearly a century after prohibition, the alcohol industry is turning a new corner on U.S. soil, and it is responding to American calls for variety, choice, and transparency.

Your smartphone camera: Meet the man behind the curtain

NVIDIA'S Kari Pulli talks about the work that goes on behind smartphone cameras and how to chop an intellectual odyssey into manageable steps.

Why it makes sense for auto foes to join forces

Fierce competitors like BMW, Toyota, Ford, and Daimler are teaming up to tackle hydrogen fuel-celled cars. It's probably the best choice they could make. Here's why.

FORTUNE -- It's lovely how a single element can bring several car companies together. Automakers are bonding to make cost-competitive vehicles that run on hydrogen, the upper-leftmost element on the periodic table.

On January 24, BMW and Toyota (TM) announced that they would collaborate to release MORE

Making music out of your mistakes

Stomp's John Angeles talks about leading without speaking, playing through mistakes, and how to make music with trashcans.

FORTUNE -- Imagine managing a room full of people with completely different backgrounds. Now give them trashcan lids to bang while you try to communicate. Now, also, dance.

This is a simplified version of John Angeles' everyday challenge as part of the off-Broadway show Stomp. It is an extremely physical show -- performers maneuver MORE

How Marriott held on to staffers through tough times

Marriott CEO Arne Sorenson talks about expanding in China, appealing to young travelers, and the business case for being a Best Company to Work For.

FORTUNE -- Arne Sorenson is the first person of non-Marriott lineage to lead this global hotel franchise. He became CEO of Marriott (No. 64 on this year's Best Companies to Work For list) in March 2012, but had been working for the company since the spring MORE

Boeing's Dreamliner mess: Simply inevitable?

Boeing's 787 Dreamliner has been plagued with glitches and delays. Still, there probably isn't a company who could have rolled it out better.

FORTUNE -- This ain't Kitty Hawk. Any aircraft creator on the cutting edge of technology needs much more than two brilliant men and a glider. Take Boeing's new 787 Dreamliner plane: Boeing had to work in concert with government regulators and more than 900 subcontractors to get this MORE